Combined BRAF/MEK inhibition for BRAF-mutant melanoma brain metastases in pregnancy: A case report.

ABSTRACT: Melanoma is a highly aggressive malignancy with the potential to metastasize to the placenta and fetus. Pregnancy-associated melanoma (PAM) complicated by brain metastases (MTS) is exceedingly rare, and its management requires balancing maternal survival with fetal safety. A 35-year-old pregnant woman with a history of superficial spreading melanoma presented at 24 weeks of gestation with multiple brain MTS. Following multidisciplinary consultation and after obtaining informed consent, two symptomatic brain MTS were surgically resected during pregnancy. Histopathology and immunohistochemistry confirmed metastatic melanoma, and molecular testing identified a B-Raf proto-oncogene serine/threonine kinase V600E mutation. Due to disease progression, targeted therapy with dabrafenib and trametin

SUBMITTER: Melus J 

PROVIDER: S-EPMC12592975 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature