<i>APOE4-APP</i> interactions exert early influences on cerebrovascular structure and function: implications for Alzheimer's disease.

ABSTRACT:

Background

APOE4 and APP are two of the main genetic risk factors for Alzheimer's disease (AD). Although there have been suggestions that these two factors interact, most of the in vivo evidence for such interactions comes from transgenic mouse models that suffer from complications associated with protein overexpression. Our goal was to examine the consequences of interactions between APOE4 and APP on brain function while avoiding the use of transgenic mice.

Methods

We generated and characterized double-mutant knock-in mice incorporating familial APP mutations and humanized APOE4.

Results

In the brains of 3-month-old double-mutant mice there were significant alterations in vascular remodeling genes, vascular structure a

SUBMITTER: Guo L 

PROVIDER: S-EPMC12592981 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature