Design and synthesis of isoxazole-functionalized benzene sulphonamides as novel inhibitors of <i>Mycobacterium tuberculosis</i> β-carbonic anhydrases.

ABSTRACT: The escalating prevalence of multidrug-resistant tuberculosis (MDR-TB) underscores the urgent need for new classes of antitubercular agents targeting novel pathways. Carbonic anhydrase, a ubiquitous metalloenzyme, catalyses the reversible hydration of carbon dioxide in the CO₂ + H₂O ⇋ HCO₃ ^- + H⁺ reaction. Suppressing this enzymatic activity has recently been identified as a new pathway for the treatment of Mycobacterium tuberculosis. To address this, a series of isoxazole-sulphonamides was rationally designed, incorporating an isoxazole pharmacophore as the aromatic tail, amide as a linker, and sulphonamide as the zinc-binding group. These compounds were evaluated against Mycobacterium tuberculosis carbonic anhydrases (M

SUBMITTER: Bandela R 

PROVIDER: S-EPMC12593002 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature