Baitong Decoction Ameliorates DSS-Induced Colitis via Modulation of STING and JAK/STAT Pathways.

ABSTRACT: Baitong decoction (BTD), a classical traditional Chinese medicine formulation, is widely recognized for its pharmacological potential in treating digestive diseases, yet its mechanisms of action in ulcerative colitis (UC) remain unclear. This study investigated the therapeutic effects of BTD in a dextran sodium sulfate (DSS)-induced murine model of UC, using six mice per group. The chemical profile of BTD was standardized via HPLC. Treatment with BTD significantly ameliorated UC symptoms, including weight loss, disease activity index (DAI) scores, colon shortening, and histopathological damage. AB-PAS staining indicated that BTD restored goblet cell numbers and mucus secretion. Additionally, BTD reduced levels of proinflammatory cytokines (TNF-α, IL-1β, IL-6, IL-18) and myeloperoxidase (MP

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12593019 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature