Toward Glycomimetic Immunomodulators: A Synthetic Dissection of <i>Phocaeicola vulgatus</i> Core Oligosaccharides and Their Recognition by DC-SIGN.

ABSTRACT: Gut microbiota play a pivotal role in maintaining immune homeostasis, with Phocaeicola vulgatus emerging as a key commensal bacterium modulating host inflammatory responses. Central to this immunomodulatory effect is its lipopolysaccharide (LPS), whose core oligosaccharide region has been implicated in selective recognition by dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN). Here, we present the efficient synthesis of a diverse set of oligosaccharide fragments from the P. vulgatus LPS core, providing a molecular toolkit to investigate their recognition by DC-SIGN. This novel synthetic approach enabled the generation of structurally well-defined glycans, which were further characterized by using a multidisciplinary strategy combining NM

SUBMITTER: Rai D 

PROVIDER: S-EPMC12593043 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature