Inclusion Complexes of Stearyl Glycyrrhetinate with γ‑Cyclodextrin and Cyclodextrin-Based Metal-Organic Frameworks: Solid-State Characterization and Improved Solubility in Fasted-State Simulated Intestinal Fluid.

ABSTRACT: In this study, stearyl glycyrrhetinate (SG), a poorly water-soluble derivative of glycyrrhetinic acid, was formulated into inclusion complexes with γ-cyclodextrin (γCD) and cyclodextrin-based metal-organic frameworks (CD-MOF-1) using the evaporation method (EVP) in the solid state. Powder X-ray diffraction and differential scanning calorimetry analyses confirmed the disappearance of SG's crystalline and melting peaks, suggesting complexation and amorphization. Meanwhile, solid-state ¹³C CP/MAS NMR and near-infrared spectroscopy revealed chemical shift alternation and peak broadening in C-H and carbon signals. This demonstrates clear molecular interactions and differences in inclusion modes between the SG and the host materials. In solubility tests using fasted-state simulated in

SUBMITTER: Ohtsu A 

PROVIDER: S-EPMC12593069 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature