Diphenhydramine, Sodium Bicarbonate, or Combination for Acute Peripheral Vertigo: A Randomized Clinical Trial.

ABSTRACT:

Importance

Intravenous diphenhydramine is commonly used to treat acute peripheral vertigo but may cause sedation. Sodium bicarbonate, an alternative therapy used in Eastern countries, may relieve vertigo symptoms without lethargy. However, comparative evidence is limited.

Objective

To evaluate the efficacy and safety of diphenhydramine, sodium bicarbonate, and their combination in treating acute peripheral vertigo among emergency department (ED) patients.

Design, setting, and participants

A triple-arm, double-blind, randomized clinical trial was conducted at the National Taiwan University Hospital, Yunlin Branch ED, from January 17 to November 14, 2023. Adults with peripheral vertigo within 24 hours of onset were enrolled. Exclusion criteria included refusal, pregnanc

SUBMITTER: Chi CY 

PROVIDER: S-EPMC12593102 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature