Management of stage IVa thymoma with coexistence of Lambert-Eaton myasthenic syndrome and myasthenia gravis in a postpartum female case report.

ABSTRACT:

Background

Thymoma is a rare malignancy accounting for less than 2% of annual cancer diagnoses. While commonly associated with myasthenia gravis (MG), its association with Lambert-Eaton myasthenic syndrome (LEMS), a paraneoplastic syndrome typically linked to small cell lung cancer, is rare. Even rarer are cases with overlapping features of both syndromes.

Case description

We report a 36-year-old postpartum Asian woman with overlapping clinical features of LEMS and MG attributed to her stage IVa thymoma, and minimally responsive to chemotherapy, thus requiring aggressive surgical debulking with cardiopulmonary bypass (CPB). She presented 2.5 weeks postpartum with dyspnea and right pleuritic chest pain. Computed tomography (CT) imaging demonstrated a >20 cm heterogeneous righ

SUBMITTER: Gochi AM 

PROVIDER: S-EPMC12593133 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature