The Vortex-Slurry Implementation: A Cheap, Easy, and Ultrafast Mechanochemical Tool to Synthesize/Screen Pharmaceutical Salts and Cocrystals.

ABSTRACT: The vortex-slurry implementation is a combination of the best insights taken from multiple solid-state methods using accessible tools to improve the physical scenario, mainly designed for the supramolecular synthesis of new multicomponent pharmaceutical solid forms by coupling mechanochemistry and slurry techniques within a vortex mixer. The proposal of the vortex-slurry implementation is to provide a totally different experimental ambient capable of reaching new 3D thermodynamic states, not allowed in the current commercial mechanochemistry methods (1D mixer mill and 2D planetary mill). The obtained compounds could be easily scaled from milligrams to grams, thus opening the door for the possibility of an industrial scaling approach. The improvements achieved by this new implementation wer

SUBMITTER: N de Souza P 

PROVIDER: S-EPMC12593158 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature