Isomeric Imidazopyridine-Based NHC Ligands: Enhanced Catalytic Activity of an Electron-Donating Remote NHC in a PEPPSI-Type Palladium Complex.

ABSTRACT: We report the synthesis and characterization of a new series of imidazopyridine-based N-heterocyclic carbene (NHC) ligands, including three unique binding modes: less atom-stabilized (C5-bound), remote normal (C7-bound), and remote mesoionic (C8-bound) configurations. These distinct ligands were incorporated into palladium-(II) complexes of both mixed phosphine/NHC and PEPPSI-type structures to investigate the ligands' electron-donating properties and their catalytic properties. Spectroscopic and computational analyses revealed that the C7-bound remote NHC ligand exhibits the highest electron-donating ability, with a unique balance of σ-donating and π-accepting characteristics that significantly enhance catalytic performance. The catalytic efficiency of the C7-bound NHC ligand, as d

SUBMITTER: Chang YC 

PROVIDER: S-EPMC12593163 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature