Smart biocomposite hydrogels in action: unraveling the roles of lignin, temperature, and crosslinker on drug release.

ABSTRACT: In this study, the release kinetics of a model water-soluble drug, caffeine, from thermoresponsive biocomposites, comprised of lignin, poly(N-isopropylacrylamide) (PNIPAm), and poly(vinyl alcohol) (PVA) were studied. Specifically, two series of soft biocomposites were fabricated-one containing softwood Kraft lignin at a 2 : 2 : 1 (lignin : PNIPAm : PVA) mass ratio and one at a 2 : 3 (PNIPAm : PVA) mass ratio, with the latter serving as a control membrane to those containing lignin. The crosslink density of these soft biocomposites was altered by systematically varying the concentrations of both glutaraldehyde, the crosslinker for lignin and PVA, and methylenebisacrylamide, the crosslinker for PNIPAm, between 5 and 15 mass%, respective to the dry polymer masses. At room temperature,

SUBMITTER: Wolff M 

PROVIDER: S-EPMC12593194 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature