Genetic association analyses of cognitive performance across multi-ancestry older adults: Application of Tobit models.

ABSTRACT: BackgroundPrevious studies investigating associations between genetic variants and late-onset Alzheimer's disease (LOAD)-related cognitive functions included primarily European-ancestry individuals and utilized linear models on neuropsychological test scores with ceiling effects.ObjectiveInvestigate associations between LOAD-related single nucleotide polymorphisms (SNPs) and neuropsychological test scores by applying the superior approach, Tobit (versus linear) regression models, to identify population-specific SNPs associated with cognitive performance across multiple genetic ancestry groups.MethodsNational Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) and Alzheimer's Disease Genetics Consortium (ADGC) provided phenotype and genotype data on Alzheimer's Disease Research Ce

SUBMITTER: Wu X 

PROVIDER: S-EPMC12593228 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature