Biomineralization-inspired scaffolds using citrate-based polymers to stabilize amorphous calcium phosphate promote osteogenesis and angiogenesis for bone defect repair.

ABSTRACT: Bone defect repair requires bone mineralization, during which amorphous calcium phosphate (ACP) plays a critical role in the formation and phase transformation of bone apatite. ACP-based biomaterials continuously release calcium and phosphate, promoting the deposition and maturation of bone minerals. This effectively overcomes the limitations of insufficient osteoinductivity of crystalline calcium phosphate (CaP) phases such as hydroxyapatite (HA). However, the instability of ACP leads to its spontaneous conversion into stable CaP phases, reducing its inherent osteogenic potential. Therefore, stabilizing ACP to maintain its bioactivity is crucial for bone repair biomaterials. Inspired by the bone biomineralization and the natural stabilization of ACP by citrate in bone, we developed a poro

SUBMITTER: Chen J 

PROVIDER: S-EPMC12593460 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature