Platelet count and sleep quality in immune thrombocytopenia: correlation with 5-hydroxytryptamine and therapeutic implications of platelet-5-HT-melatonin axis dysregulation.

ABSTRACT:

Background

Immune thrombocytopenia (ITP) disrupts platelet homeostasis via autoimmune mechanisms, yet its systemic effects beyond bleeding risk remain poorly characterized. Sleep disturbances are frequently reported in ITP patients, but the relationship between thrombocytopenia, serotonergic signaling, and sleep architecture remains undefined. This study investigates whether platelet dynamics modulate sleep quality through the "platelet-5-HT-melatonin axis" and explores therapeutic implications of this axis in ITP.

Methods

In a prospective longitudinal cohort of 87 ITP patients (baseline platelet count: 28.7 ± 15.2 × 10⁹/L) and 71 healthy controls, sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI) at baseline and after 12 weeks of standar

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC12593468 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature