Diagnostic implication of left atrial stiffness index in patients with SLE with left ventricular diastolic dysfunction.

ABSTRACT:

Objective

The left atrial stiffness index (LASI) has been proven to be a promising marker for assessing left atrial (LA) and left ventricular diastolic functions. This study aimed to evaluate the implication of LASI in diagnosing left ventricular diastolic dysfunction (LVDD) in patients with SLE.

Methods

145 patients diagnosed with SLE were enrolled and subdivided into two groups based on the absence of concomitant lupus nephritis (LN). Additionally, a control group comprising 57 healthy volunteers was recruited. Speckle tracking echocardiography (STE) was performed in all participants. Conventional parameters and the LA strains were obtained, and LASI was calculated.

Results

(1) Patients with SLE presented significantly increased LA size and reduced function, with a

SUBMITTER: Zhong X 

PROVIDER: S-EPMC12593505 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature