Investigating the Shared Genetic Architecture of 3 Age-Related Ocular Disorders.

ABSTRACT:

Purpose

To explore the shared genetic architecture, causal relationships, and cell type-specific expression patterns of pleiotropic genes in age-related macular degeneration (AMD), cataract, and primary open-angle glaucoma (POAG), uncovering molecular mechanisms and informing targeted therapies.

Design

A genetic association study combined with cross-trait meta-analyses, Mendelian randomization analyses, and single-cell RNA sequencing (scRNA-seq) analysis.

Subjects

The data related to 3 age-related ocular diseases, including AMD, cataract, and POAG, were obtained from publicly available genome-wide association study (GWAS) databases.

Methods

We conducted a comprehensive genetic analysis utilizing GWAS summary statistics to examine genetic correlations among AMD,

SUBMITTER: Bai ZP 

PROVIDER: S-EPMC12593574 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature