Robust and ultra-stable nanohesive-based solid-like slippery coating under dynamic blood flow environment for durable prevention of thrombosis and biofouling.

ABSTRACT: Biomedical devices face thrombosis and infection risks due to nonspecific bioadhesion. Although liquid-infused surfaces (LIS) exhibit anti-biofouling potential, lubricant loss under blood flow limits their utility. An innovative "solid-like" slippery coating (SSC) addresses this via amino-functionalized SiO₂ nanoparticles anchoring carboxy terminated silicone oil within an epoxy resin matrix. The collective effects of electrostatic interactions, hydrogen bonds and van der Waals forces between nanoparticles and silicone oil, in combination with epoxy resin encapsulation and dense microstructures form by the cross-linked nanoparticles, ensure lubricant retention and mechanical stability. Benefiting from the "slippery" properties, SSC exhibits exceptional resistance to various aque

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12593591 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature