<i>Brugia malayi</i> miRNAs and potential targets within the feline host (<i>Felis catus</i>).

ABSTRACT: Host specificity is a critical feature of the survival and proliferation of parasites. In the context of interactions with the host, numerous mechanisms have been identified, particularly in parasitic helminths, that enable manipulation of the host immune system to enhance their own survival. The evolutionary history of these interactions often results in hosts becoming disease-tolerant or asymptomatic, even when burdened with a high number of worms, until a disruption in the host's immune system can trigger a disease state. However, the molecular mechanisms underlying host specificity and the ways in which parasites alter the host's immune system remain largely unexplored. Research conducted on parasite-derived microRNAs (miRNAs) suggests they may play a role in remodeling the host to imp

SUBMITTER: Burkman E 

PROVIDER: S-EPMC12593627 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature