Immunoregulatory electrospinning fiber mediates Macrophage energy metabolism reprogramming to promote burn wound healing.

ABSTRACT: Burn wound management posed substantial therapeutic challenges due to impaired macrophage polarization dynamics. Metabolic dysfunction in macrophages hindered the transition from glycolysis-driven M1 phenotype to oxidative phosphorylation (OXPHOS)-driven M2 phenotype, result of perpetuating inflammatory reaction to restrain wound healing. Despite all kinds of biomaterials were developed for burn wounds, some critical issues still couldnot be solved, such as limited repair efficacy, strong immunogenicity, and high cost etc. Cellular metabolite α-ketoglutaric acid (AKG) shows good biological activity and can regulate cellular energy metabolism, which is expected to solve the above issues. However, the cellular acid-toxicity of AKG might restrict its wide application in clinic. Therefo

SUBMITTER: Wu H 

PROVIDER: S-EPMC12593653 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature