Neuroprotective effects of cobalt oxide nanoparticles through mitigating oxidative stress and reactive glial responses in traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) is a leading global cause of mortality and long-term neurological deficits. TBI involves primary mechanical damage and secondary injury processes, including oxidative stress and reactive glial responses. Oxidative stress, driven by excessive reactive oxygen species (ROS), exacerbates neuronal damage, causing cellular apoptosis and prolonged inflammation. Traditional antioxidants have limited efficacy due to poor bioavailability and targeting. Nanotechnology-based antioxidants offer a promising alternative due to their intrinsic antioxidative activities. In the present study, we explored the neuroprotective effects of dimercaptosuccinic acid-coated cobalt oxide nanoparticles (Co₃O₄ NPs) in a mouse TBI model. Co₃O₄ NPs

SUBMITTER: Qiu X 

PROVIDER: S-EPMC12593661 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature