MiDNE a tool for Multi-omics genes and drugs interactions discovery.

ABSTRACT: The availability of models representing molecular interactions in complex pathologies is essential for understanding their molecular setup and identifying therapeutic vulnerabilities. In this context, the advent of high-throughput technologies has enabled the rapid and cost-effective profiling of multiple omics layers, driving a paradigm shift from generalized models to disease-specific, context-aware modeling approaches. While the analysis of individual omics layers can provide information about specific aspects of cellular biology for a given disease, it often fails to capture complex interactions among molecules and drugs operating across different regulatory levels. Here, we introduce MiDNE (Multi-omics genes and Drugs Network Embedding), a novel computational framework that integrates

SUBMITTER: Brandi A 

PROVIDER: S-EPMC12593681 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature