FDG-PET anterior cingulate cortex hypometabolism as a marker of cerebral small vessel disease in Alzheimer's and vascular cognitive impairment and dementia.

ABSTRACT:

Background

The anterior cingulate cortex (ACC) is an important hub in the executive and salience networks. While fluorodeoxyglucose-positron emission tomography (FDG-PET) is valuable in dementia diagnosis, there is no FDG-PET imaging 'signature' in vascular cognitive impairment and dementia (VCID). We investigated whether ACC hypometabolism on FDG-PET brain imaging in people with VCID correlated with cerebral small vessel disease (CSVD), estimated via white matter hyperintensity (WMH) severity, and clinical features, comparing these results with an Alzheimer dementia (AD) cohort.

Methods

We performed a retrospective clinical database review of patients seen at a specialist cognitive neurology service between 2009 and 2024 to identify patients with VCID and AD diagnoses. Demo

SUBMITTER: Thomas ST 

PROVIDER: S-EPMC12593690 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature