NIR-absorbing organic charge transfer complexes for photothermal antibacterial therapy and wounds healing.

ABSTRACT: Bacterial infections and subsequent inflammation are major obstacles to efficient wound healing and present an increasing clinical challenge due to rising antimicrobial resistance. Photothermal therapy (PTT) offers a non-antibiotic, spatiotemporally controllable strategy to eradicate pathogens. However, the development of promising photothermal agents with high NIR response, biocompatibility and facile preparation is still challenging. Here we report supramolecular assembled donor-acceptor charge-transfer complex (CTC) nanoparticles TPD-TCB (TT NPs) achieved by precise modulation of energy-level engineering between commercially available donor and acceptor molecules. CTC formation yields a narrowed effective HOMO-LUMO gap, which enables TT NPs to exhibit broad NIR absorption extending towa

SUBMITTER: Bai P 

PROVIDER: S-EPMC12593712 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature