Biomimetic selenium nanomedicine with homologous targeting enhances hepatocellular carcinoma therapy.

ABSTRACT: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with limited effective therapeutic options. While trace elements like selenium (Se)-based nanoparticles (SeNPs) show promising anti-tumor effects, their clinical application is greatly hindered by poor targeting efficiency. Here, we engineered a biomimetic Se nanomedicine, CCEVSe, by encapsulating SeNPs within tumor cell-derived extracellular vesicles (CCEVs). Utilizing the inherent homotypic targeting and immune-evasion properties of CCEVs, CCEVSe selectively targets and is effectively internalized by tumor cells of the same origin. In vitro studies confirmed that CCEVSe exhibits superior cytotoxicity by amplifying intracellular reactive oxygen species and inhibiting key malignant behaviors, including proliferation, s

SUBMITTER: Cui F 

PROVIDER: S-EPMC12593715 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature