Genetic Insights Into Skin Diseases and Depression: Evidence From East Asian Mendelian Randomization Analysis.

ABSTRACT:

Background

This Mendelian randomization (MR) study systematically examines the causal links between skin disorders and depression in individuals of East Asian descent.

Methods

MR analysis employed summary-level genome-wide association study (GWAS) data from East Asian populations. Exposures included six skin diseases: atopic dermatitis (AD) (n = 168,103), urticaria (n = 172,083), vitiligo (n = 13,327), systemic lupus erythematosus (SLE) (n = 51,009), psoriasis (n = 69,688) and acne (n = 2062). Depression was assessed using major depressive disorder (MDD) data from the Psychiatric Genomics Consortium (n = 194,548). The primary analytical methods were the inverse variance weighting (IVW) and Wald Ratio. Sensitivity analyses were

SUBMITTER: Lin S 

PROVIDER: S-EPMC12593751 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature