Jaw-specific differential kinase activity profiles in human periodontal ligament stem cells under mechanical compression.

ABSTRACT:

Background

Increasing clinical and experimental evidence suggests that the upper and lower jaw exhibit pronounced functional and structural disparities that cannot be explained solely by classical anatomical differences. A central, yet unresolved question is whether periodontal ligament stem cells (PDLSCs) from these distinct regions display site-specific molecular signaling patterns in response to mechanical stress. We propose that PDLSCs derived from maxillary and mandibular regions activate distinct kinase signaling networks upon mechanical stimulation, thereby establishing a jaw-specific mechanobiological fingerprint.

Methods

PDLSCs were isolated from seven healthy donor teeth and exposed to a static compressive force of 2 g/cm². Kinase activity was profiled u

SUBMITTER: Niederau C 

PROVIDER: S-EPMC12593800 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature