Unraveling the Genetic Links: The Impacts of Antidiabetic Drugs on Stroke Risk.

ABSTRACT:

Background

Diabetes is widely recognized as a major contributor to stroke risk. Certain antidiabetic medications have demonstrated promising effects on reducing stroke incidence and improving outcomes.

Methods

To evaluate the potential impacts of antidiabetic drugs comprehensively, we developed an analytical framework that incorporates summary-based Mendelian randomization (SMR), two-sample Mendelian randomization (TSMR), and colocalization analyses. Summary statistics from the largest genome-wide association study (GWAS) of stroke and known subtypes were utilized, along with gene expression data from the blood, aorta, coronary artery, and tibial artery provided by the eQTLGen or GTEx V8 consortia.

Results

Elevated expression levels of the solute carrier family 5 memb

SUBMITTER: Chen J 

PROVIDER: S-EPMC12593820 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature