Charge Modulation at Nucleic Acid/MoS₂ Interfaces: Insights from Chronocoulometry for 2D Material-Based Biosensing.

ABSTRACT: This study examines the modulation of interfacial charge (Q _sur) at nucleic acid/MoS₂ interfaces using chronocoulometry with the goal of elucidating the roles of the charge on metal ions and properties of nucleic acids in developing adsorption-based platforms for nucleic acid detection. Specifically, we investigated the adsorption of locked nucleic acid and DNA oligomers on MoS₂ surfaces in the presence of Mg²⁺ and Na⁺, employing [Ru-(NH₃)₆]³⁺ as an electrostatically adsorbed redox probe. Q _sur was determined by removing the diffusion-controlled contribution and subtracting the adsorbed charge (Q _ads) from the total measured charge (Q _total).

SUBMITTER: Noby M 

PROVIDER: S-EPMC12593955 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature