Predictive potential of hepatocyte growth factor and bone morphogenetic proteins in lymphatic metastasis of breast cancer.

ABSTRACT:

Background

Lymph node metastasis is an important predictive factor for the prognosis of breast cancer. Bone morphogenetic protein (BMP) and hepatocyte growth factor (HGF), and its receptor MET, are involved in metastasis. However, their predictive potential in the prediction of lymph node metastasis from breast cancer has not been evaluated to date. The aim of this study is to evaluate the implication of HGF and BMPs in breast cancer lymphatic metastasis.

Methods

The association between the ligands and receptors of BMP, the regulators of HGF, and the modulators of MET were detected in Cardiff clinical breast cancer cohort and The Cancer Genome Atlas (TCGA) breast cancer ribonucleic acid (RNA) sequencing database. Predictive model of HGF and BMPs for nodal metastasis was eval

SUBMITTER: Cong BB 

PROVIDER: S-EPMC12593985 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature