Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells.

ABSTRACT:

Background

Myocardial infarction (MI) is a high-prevalence disease that threatens human survival and quality of life worldwide. Considerable evidence has suggested that periodontitis (PD) is detrimental to MI. However, the direct impact of PD on MI is unclear; which oral pathobionts contribute to and how microbial signals regulate the pathogenesis of MI remain obscure.

Methods

The effect of PD on MI was assessed in a mouse model that combined ligature-induced PD with MI. Ectopic accumulation of oral pathobionts in infarcted hearts was identified by bacterial sequencing and fluorescence in situ hybridization. Oral pathobionts-reactive B2 cells detrimental for MI were determined by flow cytometry and verified in gnotobiotic mice. Several mouse strains, including CD45.1, Kaede,

SUBMITTER: Chen BY 

PROVIDER: S-EPMC12594163 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature