Structural Variability of Pfam Domains Based on Alphafold2 Predictions.

ABSTRACT: Understanding the biological functions of proteins is one of the main goals of functional genomics. Such understanding will help control and manipulate biological processes to enhance desirable traits, including improved abiotic and biotic stress resistance in humans, animals, plants, and microbes. Protein domains, regarded as the functional building blocks of proteins, have been used extensively to predict protein function. Sequence-based approaches for protein function prediction, including the use of protein domain prediction from resources like the Pfam database, remain popular due to their reliability, low cost, and ease of use. Although the sequence variability of Pfam domains has been reported in several studies, their structural variability has been understudied. Here, we have extr

SUBMITTER: Poretsky E 

PROVIDER: S-EPMC12594177 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature