Pfs230 domain 12 is a potent malaria transmission-blocking vaccine candidate.

ABSTRACT: Malaria transmission-blocking vaccines (TBV) target sexual stage parasites that are transmitted to mosquitoes and are critical for spread of the pathogen. The clinically most advanced TBV candidate contains part of the Pro-domain (Pro) and Domain 1 (D1) of Plasmodium falciparum surface protein Pfs230. Subunit vaccines that contain other domains of Pfs230 have so far failed to induce functional antibodies. Here, we produced eight single-domain fragments of Pfs230 in Drosophila melanogaster S2 cells and assessed their immunogenicity in mouse immunizations. In addition to D1-specific antibodies, antibodies raised against D12 showed strong functional transmission-reducing activity in membrane feeding assays with cultured parasites, an activity that was complement dependent. Murin

SUBMITTER: Inklaar MR 

PROVIDER: S-EPMC12594191 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature