Wild-type and resistance-breaking strains of tomato spotted wilt virus differentially upregulate the immunosuppressive epoxyoctadecamonoenoic acid biosynthesis of its insect vector, <i>Frankliniella occidentalis</i>.

ABSTRACT: Tomato spotted wilt virus (TSWV) is a highly destructive plant pathogen transmitted by thrips, including Frankliniella occidentalis, in a circulative and propagative manner. To counter viral infections, thrips activate antiviral defences through C20 oxygenated polyunsaturated fatty acids (PUFAs), known as eicosanoids. However, at later stages of infection, C18 PUFAs, including epoxyoctadecamonoenoic acids (EpOMEs), modulate immune responses by preventing excessive and unnecessary activation. Our previous study demonstrated that TSWV elevates EpOME levels in thrips to suppress antiviral responses and enhance viral replication, with its nonstructural protein S (NSs) playing a key role in this process. In this study, we investigated the impact of NSs protein variation on vector immunit

SUBMITTER: Shahmohammadi N 

PROVIDER: S-EPMC12594347 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature