Effects of type 3 and neutrophilic inflammation on type 2 chronic rhinosinusitis with nasal polyps.

ABSTRACT:

Background

Chronic rhinosinusitis with nasal polyps (CRSwNP) is most commonly divided into 3 endotypes (type 1 [T1], T2, and T3) on the basis of the T-cell cytokine profiles. Although neutrophils are classically associated with T3 inflammation in chronic rhinosinusitis, neutrophilic infiltration can be present without a T3 signal.

Objective

We sought to identify the effects of T3 and neutrophilic (called neutrophil variant or Vneut) inflammation on clinical presentations and phenotype-associated mechanisms in patients with T2 CRSwNP.

Methods

We obtained 66 control ethmoid tissues and 158 nasal polyps (NPs). We measured mRNA markers for T1, T2, T3, and Vneut inflammation by quantitative RT-PCR and whole RNA expression profiles by bulk RNA sequencing. We investigated as

SUBMITTER: Oka A 

PROVIDER: S-EPMC12594462 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature