Defining the Enterococcus faecalis Fatty Acid Kinase System of Exogeneous Fatty Acid Utilization.

ABSTRACT: Phospholipid synthesis in Firmicute bacteria differs markedly from that of the paradigm Escherichia coli pathway in that acyl phosphates are a key intermediate. Acyl phosphates are required for the first acylation step of the phospholipid synthesis pathway catalyzed by the PlsY acyltransferase and are synthesized by two different pathways. In the absence of exogenous fatty acids, de novo synthesized acyl-acyl carrier protein (ACP) species are converted to acyl phosphates by the PlsX acyl-ACP: phosphate acyltransferase, which transfers the acyl chain from ACP to inorganic phosphate. When exogenous fatty acids are present, these acids are converted to acyl phosphates by the FakAB fatty acid kinase and can be converted to acyl-ACPs via PlsX. The active kinase is composed of the ATP-requiring

SUBMITTER: Dong H 

PROVIDER: S-EPMC12594616 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature