Design of Hybrid Bioactive Peptides Derived From Cecropin and Cathepsin for Therapeutic Application.

ABSTRACT: The escalating global health crisis of antimicrobial resistance demands the urgent development of novel therapeutic agents with new mechanisms of action. Bioactive peptides (BAPs), and specifically antimicrobial peptides (AMPs), represent a highly promising class of candidates due to their broad-spectrum activity and superior biocompatibility compared to conventional antibiotics. This manuscript presents a novel approach to drug discovery by designing multifunctional hybrid peptides through the strategic fusion of conserved domains from cecropin and cathepsin-derived sequences. We established an integrated in silico pipeline, utilizing machine learning for activity prediction and comprehensive ADMET profiling to rationally select three lead candidates with optimal physicochemical propertie

SUBMITTER: Cepinho GS 

PROVIDER: S-EPMC12594624 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature