Obstructive Sleep Apnoea and Risk of Fragility Fracture in Patients With Type 2 Diabetes: A Population-Based Retrospective Cohort Study.

ABSTRACT:

Objective

This study examines the risk of fragility fractures in patients with type 2 diabetes (T2D) who have obstructive sleep apnoea (OSA) compared to those without OSA.

Method

This retrospective cohort study uses UK primary care data from 2000 to 2022. T2D patients without prior fragility fractures were included. Patients with OSA were matched with up to 4 non-OSA patients based on age, sex, BMI and T2D duration. Two cohorts were analysed based on whether OSA was diagnosed before (cohort 1) or after (cohort 2) the T2D diagnosis. Hazard ratios were calculated using a Cox proportional hazards model.

Results

Cohort 1 included 19,795 patients with OSA and 64,124 without OSA. Cohort 2 included 21,769 patients with OSA and 66,350 without OSA. OSA was associated with an i

SUBMITTER: Makhdom EA 

PROVIDER: S-EPMC12594633 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature