Contemporary Oral Medication Use and Frequency in Patients with Transthyretin Amyloid Cardiomyopathy.

ABSTRACT:

Introduction

Transthyretin amyloid cardiomyopathy (ATTR-CM) is an increasingly recognized cause of heart failure (HF), with a higher prevalence in older patients with comorbidities requiring concomitant medical therapy. Acoramidis is a next-generation transthyretin stabilizer with near-complete protein stabilization (≥ 90%) administered orally twice daily (BID) for treatment of ATTR-CM. We report on oral medication use in patients with ATTR-CM using two complementary sources: the ATTRibute-CM trial and real-world claims data.

Methods

In the ATTRibute-CM study, participants with ATTR-CM were randomly assigned 2:1 to receive 800 mg of acoramidis hydrochloride or matching placebo BID for 30 months. Participants from acoramidis and placebo groups were pooled for this analysis. B

SUBMITTER: Dasgupta N 

PROVIDER: S-EPMC12594741 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature