Effects of acute exercise on inflammatory and metabolic biomarkers in women: a randomized controlled trial.

ABSTRACT: Mechanisms linking exercise to reduced breast cancer risk are poorly understood. 103 healthy women, 18-75, were randomized to 45-minutes of acute exercise at 60% VO₂max (N = 54, intervention), or 45-minutes of rest (N = 49, control). Blood samples were collected at baseline, 45- and 105-minutes, analytes measured by immunoassay, and mean changes from baseline to 45- and 105-minutes modelled using generalized estimating equations, adjusted for confounders. Mean percent changes levels (Δ%) increased in exercisers vs. controls for monocyte chemoattractant protein (MCP)-1 Δ^45 min + 17.1% (P < 0.0001), Δ^105 min + 12.0% (P = 0.005); interleukin(IL)-6, Δ^45 min + 103.5%, Δ^105 min + 92.3%; and at 45-minutes for glucose Δ^45 min + 8.8%

SUBMITTER: Duggan C 

PROVIDER: S-EPMC12594776 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature