Sphingomyelin synthase-related protein is a regulator of serine palmitoyltransferase.

ABSTRACT: Sphingomyelin synthase-related protein (SMSr) belongs to the SMS family; however, it cannot synthesize SM. We reported that SMSr is a phosphatidylethanolamine-specific phospholipase C, which is associated with metabolic dysfunction-associated fatty liver disease (MAFLD). However, the mechanism is unknown. Based on hierarchical clustering of the samples from the human Genotype-Tissue Expression project, we found that SMSr and serine palmitoyltransferase (SPT), the key enzyme for sphingolipid biosynthesis, as well as certain sphingolipid metabolism-related genes, belong to the same co-expression cluster in the liver and adipose tissues. We also found that Smsr expression is positively associated with Sptlc1 and Sptlc2 expression in both tissues of both genders. In a mouse study, we found tha

SUBMITTER: Li X 

PROVIDER: S-EPMC12594915 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature