Multiomics reveal plasma constituents associated with thrombosis among trauma patients who do not respond to enoxaparin.

ABSTRACT: Venous thromboembolism (VTE) is among the most common complications affecting patients with severe injuries. Although enoxaparin resistance is common, predicting which patients among this subgroup will develop VTE remains a clinical challenge. The goal of this study was to use multiomics to identify plasma constituents associated with VTE development among trauma patients exhibiting poor responses to enoxaparin. We conducted a secondary analysis of trauma patients at high risk of VTE based on injury characteristics. Plasma was collected daily for the first 8 hospital days. Patients who never responded to enoxaparin were defined as not achieving an anti-factor Xa (FXa) level of ≥0.2 IU/mL during the sampling period. A total of 145 patients were included in the analysis, of whom 24 (16.6%) d

SUBMITTER: LaCroix IS 

PROVIDER: S-EPMC12594916 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature