Long-term outcome after surgical ventricular septal defect closure: Longitudinal follow-up into the fifth decade.

ABSTRACT:

Objectives

To evaluate survival, clinical outcome and quality of life (QoL) of patients up to 49 years after surgical ventricular septal defect (VSD) closure.

Methods

Single-center, longitudinal cohort study evaluating consecutive patients with surgical VSD closure between 1968 and 1980 with extensive cardiac and QoL evaluation every decade.

Results

Of the original cohort of 174 patients, 39 died (22 %), 8 were lost to follow-up and 38 had not participated previously. Survival rate at 49 years follow-up was 77 % and 86 % when excluding early postoperative mortality. Of the 89 eligible survivors, 76 (85 %) were evaluated (59 % male, median age 49 [44-54] years) with a median follow-up of 44 (range 40-49) years after surgery. Event-free survival at 49 years was 50 %, wi

SUBMITTER: Unluturk S 

PROVIDER: S-EPMC12594936 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature