Metabolites associated with abnormal glucose metabolism responding to primary care lifestyle intervention.

ABSTRACT: Type 2 diabetes can be prevented by lifestyle intervention. We aimed to identify metabolites that associate with glucose metabolism and respond to lifestyle intervention with evidence-based targets for nutrition and physical activity in individuals at high risk of type 2 diabetes. Standard oral glucose tolerance test (OGTT) was used to categorize 624 participants into those having normal glucose tolerance (NGT), isolated impaired glucose tolerance (IGT), IGT with increased fasting glucose (IGT + IFG), and type 2 diabetes. Plasma LC-MS metabolomics was performed to reveal metabolic signatures. The baseline group differences were analysed with the Kruskal-Wallis test and the effect of intervention with a linear mixed-effects model. Significant differences in the metabolite signature were obs

SUBMITTER: Koistinen VM 

PROVIDER: S-EPMC12594967 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature