Predictors and nomogram for amputation risk in pit viper snakebite envenoming at hospital admission.

ABSTRACT: Pit viper snakebite envenoming remains a critical global health challenge, with tissue necrosis and subsequent amputation posing significant morbidity despite antivenom availability. Existing prediction tools lack integration of dynamic laboratory parameters and iatrogenic factors, limiting their clinical utility. A retrospective cohort study analyzed 1,527 pit viper snakebite envenoming cases from the People's Hospital of Lichuan City (2012-2025). Data encompassed demographics, bite characteristics, treatment timelines, and laboratory parameters (neutrophil-to-lymphocyte ratio [NLR], D-dimer, fibrinogen [FIB]). Univariate and multivariate logistic regression analyses identified independent predictors, and a nomogram was constructed using R software. Model performance was evaluated via are

SUBMITTER: Fu G 

PROVIDER: S-EPMC12594999 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature