Added value of serum proteins to clinical and ultrasound information in predicting the risk of malignancy in ovarian tumors.

ABSTRACT: Assessment of Different Neoplasias in the Adnexa (ADNEX) is the best-performing model to estimate the risk of malignancy in ovarian tumors. We assessed the incremental value of serum proteins over ADNEX predictors in an exploratory multicenter study. In a cohort of 932 patients with an adnexal mass scheduled for surgery, 33 serum proteins were preoperatively quantified using multiplex high-throughput and electrochemiluminescence immunoassays. Using multivariable logistic regression, ADNEX predictors alone had an area under the receiver operating characteristic curve (AUC) of 0.91 (95% confidence interval, 0.89-0.93) to discriminate benign from malignant tumors. This AUC increased most after adding HE4 (+0.03) or CA125 (+0.02). CA72.4 increased AUCs to discriminate secondary metastatic tumo

SUBMITTER: Coosemans A 

PROVIDER: S-EPMC12595006 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature