Mean platelet volume and long-term cardiovascular outcomes in patients with type 2 diabetes mellitus.

ABSTRACT:

Background

Altered platelet function contributes to the prothrombotic state in type 2 diabetes mellitus (DM), potentially influencing long-term cardiovascular risk. Mean platelet volume (MPV), a readily available marker of platelet size and activity, has been linked to adverse cardiovascular outcomes, yet its prognostic value in DM is less defined. This study evaluated the association between MPV and the composite MPV × platelet count (MPV × PLT) with long-term cardiovascular outcomes in patients with DM without prior myocardial infarction (MI) or stroke.

Methods

This retrospective cohort study used anonymized data from 88,710 patients with DM and no prior history of MI or stroke. Patients were classified into three equal-sized groups based on MPV and MPV*PLT values, with ad

SUBMITTER: Dahan S 

PROVIDER: S-EPMC12595011 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature