Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line.

ABSTRACT: The P2X7 receptor is an adenosine triphosphate (ATP)-gated ion channel expressed in different cell types of the brain. Polymorphisms in the P2RX7 gene have repeatedly been associated with psychiatric disorders including major depression. Depression is a stress-related disorder in which a dysregulation of the immune system has attracted increasing attention as a potential disease mechanism. The well-documented role of P2X7 in inflammatory conditions advocates its involvement in immune system dysregulation and depression genesis. However, understanding its exact role requires further research using appropriate animal models. Unfortunately, some of the most widely used P2X7 knockout mouse models are limited in their utility by the continuous expression of certain P2rx7 splice variants or even

SUBMITTER: von Mucke-Heim IA 

PROVIDER: S-EPMC12595207 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature