Quercetin suppresses endometrial cancer stem cells via ERα-mediated inhibition of STAT3 signaling.

ABSTRACT:

Background

Quercetin, a secondary metabolite derived from plants with both medicinal and edible values, has demonstrated potential in cancer treatment, including endometrial carcinoma. However, its anti-tumor effect on cancer stem-like cells (CSCs), a subpopulation considered to be a major driver of tumor recurrence and metastasis-remain largely unclear.

Aim

This study aimed to evaluate the anti-tumor effects of Quercetin by targeting CSCs and suppressing their stemness properties.

Methods

CSCs were enriched using serum-free medium and treated with a range concentration of Quercetin. The STAT3/JAK2 signalling was detected by western blot after treatment with Quercetin. The effects of Quercetin on malignant behaviours in CSCs, including proliferation, cell cycle distri

SUBMITTER: Tang O 

PROVIDER: S-EPMC12595211 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature