Causal Relationship Between Metabolic Traits and Risk of NSCLC: A Two-Sample Mendelian Randomization Analysis.

ABSTRACT: Although the impact of circulating metabolites on the immune microenvironment of lung cancer has been recognized, the causal relationship between these metabolites and non-small cell lung cancer (NSCLC) remains unclear. We investigated whether 233 metabolic traits have a causal effect on NSCLC using data from population-based genome-wide association studies (GWAS). We employed the inverse variance weighted (IVW) method with random effects as the primary analytical tool. After performing two-sample Mendelian randomization (MR) analysis of 233 metabolic traits on NSCLC risk, we selected the significant ones for further sensitivity analyses. Applying a false discovery rate (FDR) correction (P_FDR < 0.05), we identified a causal relationship between two metabolic traits and NSCLC: th

SUBMITTER: Li X 

PROVIDER: S-EPMC12595243 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature