Local Genetic Correlations and Pleiotropy Reveal Shared Genetic Architecture Between COVID-19 Phenotypes and Prostate Cancer in European Populations.

ABSTRACT: Background: While a link between coronavirus disease 2019 (COVID-19) and prostate cancer (PrCa) has been observed in clinical settings, the shared underlying genetic influences remain unclear. Methods: Leveraging summary statistics from the hitherto largest genome-wide association studies (GWASs) of European-ancestry populations, we performed the first comprehensive genome-wide cross-trait analysis to investigate the shared genetic architecture, pleiotropy, and potential causal relationships between three COVID-19 phenotypes and PrCa. Results: We found no evidence of significant genome-wide genetic correlations between COVID-19 phenotypes and PrCa (P > 0.05). However, after partitioning the whole genome into 2353 independent regions, we observed significant loca

SUBMITTER: Xiang R 

PROVIDER: S-EPMC12595267 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature